Various polymers, including natural, synthetic and natural/synthetic hybrid polymers, have been used to make hydrogels via chemical or physical crosslinking. Hydrogels are attractive scaffolding materials owing to their highly swollen network structure, ability to encapsulate cells and bioactive molecules, and efficient mass transfer. This article summarizes the recent progress in the design and synthesis of hydrogels as tissue-engineering scaffolds. We propose that physical and topographical properties of PCL, PLLA, their blend and copolymer are of a great dependence of chemical structure but could be changed during the manufacturing process that will lead to changes in biological properties.ĭesign properties of hydrogel tissue-engineering scaffolds PCL PLLA scaffolds had the highest average pore area (pactive phase of adhesion process. The aim of the study is to compare physical, topographical and biological properties of polycaprolactone (PCL), poly-L-lactic acid (PLLA), polycaprolactone + poly-L-lactic acid blend (PCL PLLA), L-lactide/Caprolactone copolymer (PLC7015) scaffolds fabricated with the same fiber thickness using electrospun technology. are becoming the most important aspects for effectiveness of prosthesis biofunctionalization because of their great impact on cell adhesion, spreading, cell proliferation, differentiation and cell function. Such material characteristics as mechanical properties, chemical structure, nano- and micro topography, surface charge, porosity, wettability etc. Golovkin, A.īiodegradable polymers (blends, copolymers) could be the ideal materials for manufacturing of scaffolds for small diameter vascular graft. Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffoldsīolbasov, E.
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